A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age

ObjectiveTo present a definition of recurrent implantation failure that accounts for the effects female age and anticipated blastocyst euploidy rates on cumulative rates.DesignMathematical modeling.SettingNot applicable.Patient(s)Not applicable.Intervention(s)Mathematical modeling probability basis published across categories age.Main Outcome Measure(s)The number blastocysts required to achieve 95% under assumption absence any other factor affecting implantation.Result(s)When status transferred embryo is unknown (i.e., not subjected preimplantation genetic testing aneuploidies), our simulation shows no category reaches at least one until after transfer seven blastocysts. The reach same threshold higher older patients. For example, women than 38 years require more 10 untested upper range predictive meet 95%. On hand, if rate euploid assumed be 55%, then 4 are enough greater 95%, regardless age.Conclusion(s)The term “recurrent failure” should functional guiding further management. We suggest called becomes reasonably likely caused by factors aneuploidy, leading cause failure. propose new in age, rate, specified implantation. To rates. Mathematical modeling. Not applicable. age. When